Adipose tissue-liver axis in alcoholic liver disease
نویسندگان
چکیده
منابع مشابه
Adipose Tissue Dysfunction and Alcoholic Liver Disease
Although much progress has been made over last three decades of research on the mechanisms underlying alcoholic liver disease (ALD), it remains an important health problem in the United States. ALD ranks among the major causes of morbidity and mortality in the world, and affects millions of patients worldwide each year [1]. The disease process is characterized by early steatosis, steatohepatiti...
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Non-alcoholic fatty liver disease (NAFLD) is the most frequent type of chronic liver disease in the pediatric age group, paralleling an obesity pandemic. A "multiple-hit" hypothesis has been invoked to explain its pathogenesis. The "first hit" is liver lipid accumulation in obese children with insulin resistance. In the absence of significant lifestyle modifications leading to weight loss and i...
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Alcoholic liver disease (ALD) is one of the leading causes of liver diseases and liver-related death worldwide. Of the many factors that contribute to the pathogenesis of ALD, gut-derived lipopolysaccharide (LPS) plays a central role in induction of steatosis, inflammation, and fibrosis in the liver. In this review, we discuss the mechanisms by which alcohol contributes to increased gut permeab...
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The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute inhibition of IKK-ε and TBK1 with amlexanox treatment increases cAMP levels in subcutaneous adipose depots of obese mice, promoting the synthe...
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BACKGROUND Osteopontin (OPN) plays an important role in the progression of chronic liver diseases. We aimed to quantify the liver, adipose tissue and serum levels of OPN in heavy alcohol drinkers and to compare them with the histological severity of hepatic inflammation and fibrosis. METHODOLOGY/PRINCIPAL FINDINGS OPN was evaluated in the serum of a retrospective and prospective group of 109 ...
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ژورنال
عنوان ژورنال: World Journal of Gastrointestinal Pathophysiology
سال: 2016
ISSN: 2150-5330
DOI: 10.4291/wjgp.v7.i1.17