Albumin-Deficient Rat: Nagase Analbuminemia Rat(NAR).
نویسندگان
چکیده
منابع مشابه
Renal processing of serum proteins in an albumin-deficient environment: an in vivo study of glomerulonephritis in the Nagase analbuminaemic rat.
BACKGROUND Plasma albumin has been considered as important for governing glomerular permselectivity as well as being tubulotoxic in proteinuric states. The purpose of this study was to examine glomerular permselectivity and protein clearance of plasma albumin-deficient Nagase analbuminaemic rats (NAR) in normal and proteinuric states associated with puromycin aminonucleoside nephrosis (PAN) and...
متن کاملEnhanced glomerular permeability to macromolecules in the Nagase analbuminemic rat.
Plasma albumin restricts capillary water filtration. Accordingly, the glomerular ultrafiltration coefficient is higher in Nagase analbuminemic rats (NAR) than in Sprague-Dawley controls. We investigated whether the glomerular permeability to macromolecules is also enhanced in NAR. SDS-PAGE fractionation of urine proteins showed several bands with molecular masses between 60 and 90 kDa in NAR on...
متن کاملSerum cholinesterase in analbuminemia.
S EVERAL SUGGESTIONS have been made to explain the parallelism between serum cholinesterase and serum albuniin levels in chronic liver disease-first recognized by Faber (i), and since, by many othersand the moderate fall in serum cholinesterase found to occur ill normal persons after the infusion of albumin (2). Kunkel and Ward (3) suggested that a normal serum albumin level was needed for the ...
متن کاملMolecular Diagnosis of Analbuminemia: A New Case Caused by a Nonsense Mutation in the Albumin Gene
Analbuminemia is a rare autosomal recessive disorder manifested by the absence, or severe reduction, of circulating serum albumin (ALB). We report here a new case diagnosed in a 45 years old man of Southwestern Asian origin, living in Switzerland, on the basis of his low ALB concentration (0.9 g/L) in the absence of renal or gastrointestinal protein loss, or liver dysfunction. The clinical diag...
متن کاملCongenital analbuminemia caused by a novel aberrant splicing in the albumin gene
INTRODUCTION Congenital analbuminemia is a rare autosomal recessive disorder manifested by the presence of a very low amount of circulating serum albumin. It is an allelic heterogeneous defect, caused by variety of mutations within the albumin gene in homozygous or compound heterozygous state. Herein we report the clinical and molecular characterization of a new case of congenital analbuminemia...
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ژورنال
عنوان ژورنال: Proceedings of The Japanese Association of Animal Models for Human Diseases
سال: 1991
ISSN: 0911-2057,1884-4189
DOI: 10.1538/expanim1985.7.7