Antipyrine kinetics in liver disease and liver transplantation

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Antipyrine kinetics in liver disease and liver transplantation.

Antipyrine kinetics were studied in seven normal subjects, 10 patients with liver disease, and 13 clinically stable patients who received a liver transplant. Five patients were studied both before and after liver transplantation. Antipyrine concentrations in saliva after oral dosing were measured by HPLC. The antipyrine t1/2 was significantly longer (P less than 0.05) in patients with liver dis...

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ژورنال

عنوان ژورنال: Clinical Pharmacology and Therapeutics

سال: 1986

ISSN: 0009-9236,1532-6535

DOI: 10.1038/clpt.1986.57