منابع مشابه
Could antiretroviral neurotoxicity play a role in the pathogenesis of cognitive impairment in treated HIV disease?.
Whilst effective antiretroviral therapy is protective against the more severe forms of HIV-associated brain disease, there remains a large burden of clinically symptomatic cognitive impairment in the modern era. Although several potential pathogenic mechanisms have been proposed, the underlying pathology remains elusive. In this review, we summarize the evidence describing neuronal toxicity of ...
متن کاملLithium neurotoxicity.
Inspite of the advent of newer antimanic drugs, lithium carbonate remains widely used in the treatment and prevention of manic-depressive illness. However care has to be exercised due to its low therapeutic index. The central nervous system and renal system are predominantly affected in acute lithium intoxication and is potentially lethal. The more common side effect involves the central nervou...
متن کامل4 Neurotoxicity
Guidelines for testing existing neurotoxicity under the Toxic Substances chemicals for Control Act (TSCA) have been published by the U.S. Environmental Protection Agency (EPA). While the current regulatory process for assessing existing chemicals under TSCA does not use a tier-testing approach, there is widespread support for tier-testing processes. However, there is general disagreement betwee...
متن کاملLithium neurotoxicity.
The peripheral and central neurotoxic effects of lithium carbonate are illustrated by 4 case histories. Lithium neurotoxicity is likely to be more common than the literature suggests. Neurological sequelae may be irreversible and may be associated with therapeutic serum levels. Prevention may be facilitated by more stringent case selection, EEG and clinical monitoring and the development of imp...
متن کاملPrion Neurotoxicity 51 Prion Neurotoxicity: Insights from Prion Protein Mutants
The chemical nature of prions and the mechanism by which they propagate are now reasonably well understood. In contrast, much less is known about the identity of the toxic prion protein (PrP) species that are responsible for neuronal death, and the cellular pathways that these forms activate. In addition, the normal, physiological function of cellular PrP (PrPC) has remained mysterious, hamperi...
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ژورنال
عنوان ژورنال: Journal of NeuroVirology
سال: 2012
ISSN: 1355-0284,1538-2443
DOI: 10.1007/s13365-012-0120-3