Biguanide Antidiabetic Drugs: Imeglimin Exhibits Higher Proton Basicity but Smaller Lithium-Cation Basicity than Metformin in Vacuo
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چکیده
منابع مشابه
Optical basicity of ionic liquids.
The concept of optical basicities initially developed by Duffy for solid oxides was successfully transferred to low melting salts such as ionic liquids (ILs). Several ionic liquids (ILs) were doped with Mn(NTf(2))(2) (NTf(2) = bis(trifluoromethanesulfonyl)imide) as a probe to investigate the IL anion basicity by means of UV-Vis spectroscopy. The (6)A(1)-->(4)A, (4)E(G) transition band of Mn(2+)...
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Various biguanide derivatives are used as antihyperglycemic and antimalarial drugs (e.g., 1,1-dimethyl biguanide (metformin), phenylethyl biguanide (phenformin), N-(4-chlorophenyl)-N'-(isopropyl)-imidodicarbonimidic diamide (proguanil)); however, no common mechanism has been suggested in these controversial therapeutic actions. Biguanides bind endogenous metals that inhibit cysteine proteases i...
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Azoheteroarene photoswitches offer functional advantages over their more conventional azobenzene counterparts by virtue of their heteroaromatic ring(s). Here we report that azobis(2-imidazole) functions as a photoswitchable base due to the additional proton stabilisation that is possible in the protonated Z isomer, facilitated by the basic imidazole nitrogens. This thermodynamic difference in s...
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Differences in the extent of protonation of functional groups lying on either side of water-hydrophobe interfaces are deemed essential to enzymatic catalysis, molecular recognition, bioenergetic transduction, and atmospheric aerosol-gas exchanges. The sign and range of such differences, however, remain conjectural. Herein we report experiments showing that gaseous carboxylic acids RCOOH(g) begi...
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For example, in the self-ionization of water we see that two water molecules collide to react and form a hydroxide ion and a hydronium ion. Each reaction begins first by an electrostatic attraction between an electron rich and an electron poor region of the reactants. Hydrogen bonding occurs between the electron deficient hydrogen of one water molecule with the electron rich oxygen of another w...
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ژورنال
عنوان ژورنال: ACS Omega
سال: 2018
ISSN: 2470-1343,2470-1343
DOI: 10.1021/acsomega.8b02507