Blocking myostatin: muscle mass equals muscle strength?
نویسندگان
چکیده
منابع مشابه
Myostatin Neutralization Results in Preservation of Muscle Mass and Strength in Preclinical Models of Tumor-Induced Muscle Wasting.
Skeletal muscle wasting occurs in a great majority of cancer patients with advanced disease and is associated with a poor prognosis and decreased survival. Myostatin functions as a negative regulator of skeletal muscle mass and has recently become a therapeutic target for reducing the loss of skeletal muscle and strength associated with clinical myopathies. We generated neutralizing antibodies ...
متن کاملLong-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors.
Increasing the size and strength of muscles represents a promising therapeutic strategy for musculoskeletal disorders, and interest has focused on myostatin, a negative regulator of muscle growth. Various myostatin inhibitor approaches have been identified and tested in models of muscle disease with varying efficacies, depending on the age at which myostatin inhibition occurs. Here, we describe...
متن کاملAnti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice.
Sarcopenia, or skeletal muscle atrophy, is a debilitating comorbidity of many physiological and pathophysiological processes, including normal aging. There are no approved therapies for sarcopenia, but the antihypertrophic myokine myostatin is a potential therapeutic target. Here, we show that treatment of young and old mice with an anti-myostatin antibody (ATA 842) for 4 wk increased muscle ma...
متن کاملMyostatin Related Gene Associations with Muscle Mass and Strength in Humans
INTRODUCTION: The gradual decline in muscle mass with age is known as sarcopenia,
متن کاملInhibition of myostatin in adult mice increases skeletal muscle mass and strength.
A human therapeutic that specifically modulates skeletal muscle growth would potentially provide a benefit for a variety of conditions including sarcopenia, cachexia, and muscular dystrophy. Myostatin, a member of the TGF-beta family of growth factors, is a known negative regulator of muscle mass, as mice lacking the myostatin gene have increased muscle mass. Thus, an inhibitor of myostatin may...
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ژورنال
عنوان ژورنال: Journal of Cachexia, Sarcopenia and Muscle
سال: 2020
ISSN: 2190-5991,2190-6009
DOI: 10.1002/jcsm.12647