Cardiosomal microRNAs Are Essential in Post-Infarction Myofibroblast Phenoconversion
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چکیده
منابع مشابه
CXC-Type Chemokines Promote Myofibroblast Phenoconversion and Prostatic Fibrosis
Recent studies from our group suggest that extracellular matrix (ECM) deposition and fibrosis characterize the peri-urethral prostate tissues of some men suffering from Lower Urinary Tract Symptoms (LUTS) and that fibrosis may be a contributing factor to the etiology of LUTS. Fibrosis can generally be regarded as an errant wound-healing process in response to chronic inflammation, and several s...
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Benign prostate hyperplasia (BPH), an enlargement of the prostate common in aging in men, is associated with urinary voiding dysfunction manifest as Lower Urinary Tract Symptoms (LUTS). Although inflammation and abnormal smooth muscle contractions are known to play key roles in the development of LUTS, tissue fibrosis may also be an important and previously unrecognized contributing factor. Tis...
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The complexity of posttranscriptional regulation by noncoding microRNAs (miRNAs, miRs) is still not completely understood. A large fraction of the genome is under the control of miRs via (partial) complementary base pairing within the corresponding mRNA region. Myocardial infarction is characterized by strongly altered gene expression, deregulation of underlying signaling pathways, and crucial ...
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AIMS Circulating microRNAs (miRNAs) may represent a novel class of biomarkers; therefore, we examined whether acute myocardial infarction (MI) modulates miRNAs plasma levels in humans and mice. METHODS AND RESULTS Healthy donors (n = 17) and patients (n = 33) with acute ST-segment elevation MI (STEMI) were evaluated. In one cohort (n = 25), the first plasma sample was obtained 517 ± 309 min a...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2019
ISSN: 1422-0067
DOI: 10.3390/ijms21010201