Chemorepulsion of developing motor axons by the floor plate
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چکیده
منابع مشابه
Chemorepulsion of developing motor axons by the floor plate
In the developing nervous system, motor axons grow away from the ventral midline floor plate, suggesting that the latter might be a source of repulsive axonal guidance cues. In donor to host transplantation experiments, ectopic pieces of floor plate were positioned between chick hindbrain motor neurons and their exit points. Immunohistochemistry and retrograde axonal labeling techniques demonst...
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During development of the vertebrate CNS, commissural axons initially grow circumferentially toward the ventral midline floor plate. After crossing the floor plate, they abruptly change their trajectory from the circumferential to the longitudinal axis. Although recent studies have unraveled the mechanisms that control navigation of these axons along the circumferential axis, those that result ...
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In the bilaterally symmetrical vertebrate CNS, all developing axons must choose between remaining on the same side of the midline or growing across it. The mechanism underlying this axonal pathfinding is, however, poorly understood. Here we demonstrate that the ventral midline floor plate (FP) chemorepels two types of ipsilaterally projecting axons, one from the alar plate and another from the ...
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During early neurogenesis, the floor plate plays an essential role(s) in the differentiation of the ventral portion of neural tube. In this study, we detected the specific distribution of unique glycoconjugate during the floor plate differentiation. Formalin fixed paraffin sections of BALB/c mice (10-14 embryonic days) were processed for histochemical studies using horseradish peroxidase-labell...
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ژورنال
عنوان ژورنال: Neuron
سال: 1995
ISSN: 0896-6273
DOI: 10.1016/0896-6273(95)90260-0