Chloroquine-induced lipidosis mimicking Fabry disease

  • DianaAlbay
  • Sharon GAdler
  • JayaPhilipose
  • C CCalescibetta
  • Stephen GRomansky
  • Arthur HCohen

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Hydroxychloroquine-induced lipidosis of the kidney mimicking Fabry disease: a case report

A 51-year-old female patient with Sjogren’s syndrome had a renal insufficiency after 2 months’ history of hydroxychloroquine therapy (300 mg/d, cumulative dose of about 18 g). The renal biopsy suggested Fabry disease. The gene analysis and plasma a-galactosidase A activity were in the normal range. After quitting the therapy of hydroxychloroquine, the renal function returned to its normal state...

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Article info

Journal name: Modern Pathology

Year: 2004

ISSN: 0893-3952,1530-0285

DOI: 10.1038/modpathol.3800344