منابع مشابه
Synthesis of Cis-Diammine (1,1-cyclobutane dicarboxylate) Platinum(II)
Platinum-based anticancer drugs are chemotherapeutic agents to treat cancer. Carboplatin (cis diammine cyclobutane dicarboxylate platinum (II)) is a second generation drug that has less toxic than cisplatin, allowing for high dosages. In the first stage, 1,3-Cyclobutane dicarboxylic acid, a key intermediate for the preparation of carboplatin, have been synthesized in good yields using diffe...
متن کاملRole of the copper transporter, CTR1, in platinum-induced ototoxicity.
The goal of this study was to determine the role of an influx copper transporter, CTR1, in the ototoxicity induced by cisplatin, a potent anticancer platinum analog used in the treatment of a variety of solid tumors. As determined through reverse transcriptase-PCR (RT-PCR), quantitative RT-PCR, Western blot, and immunohistochemistry, mouse CTR1 (Ctr1) was found to be abundantly expressed and hi...
متن کاملcis-Dimethylbis(triphenylarsine)platinum(II)
In the title compound, [Pt(CH(3))(2)(C(18)H(15)As)(2)], the Pt(II) atom adopts a distorted cis-PtAs(2)C(2) square-planar coordination geometry. In the crystal, mol-ecules inter-act via aromatic π-π stacking inter-actions [centroid-centroid separation = 3.6741 (18) Å].
متن کاملcis-Dichloridobis(triisopropoxyphosphine)platinum(II)
The title compound, [PtCl(2)(C(9)H(21)O(3)P)(2)], was obtained from a solution of PtCl(2)(COD) (COD = 1,5-cyclooctadiene) and triisopropyl-phosphite in dichloro-methane. The complex features a Pt(II) atom coordinated by two Cl and two P atoms, yielding a slightly distorted cis square-planar geometry.
متن کاملIntra-arterial cis-platinum in osteosarcoma.
Conventional radiography continues to be the most important imaging modality in the initial diagnosis and assessment of skeletal neoplasms. However, this technique is usually inadequate to determine the local extent of the tumor, particularly in malignancies. Angiography also fails to define accurately the local extent of most skeletal neoplasms. Computed tomography, however, demonstrates the i...
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ژورنال
عنوان ژورنال: The Laryngoscope
سال: 1991
ISSN: 0023-852X
DOI: 10.1288/00005537-199109000-00001