Comparison of Finasteride, Metformin, and Finasteride Plus Metformin in PCOS

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Metformin-Clinical Pharmacology in PCOs

Oligo-anovulation, hyperandrogenism and insulin resistance characterizes polycystic ovary syndrome (PCOs). Metformin is the oldest insulin sensitizer used in the management of type 2 diabetes mellitus. In PCOs, metformin decreases the serum lipids, androgen and insulin; induces ovulation and regular menstrual cycle; increases the pregnancy rate.

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Metformin-letrozole in comparison with Metformin-clomiphene citrate in clomiphene-resistance PCOS patients undergoing IUI

BACKGROUND Polycystic ovary syndrome (PCOS) is associated with approximately 75% of women who suffer from infertility due to anovulation. Additionally, around 20- 25% of anovulatory women with PCOS do not respond at all to clomiphene citrate and are considered to be "clomiphene- resistant". Aromatase inhibitors have been suggested as an alternative treatment to clomiphene as the discrepancy bet...

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How Metformin Acts in PCOS Pregnant Women

OBJECTIVE Metformin has been reported to reduce the risk of gestational diabetes (GD) in women with polycystic ovarian syndrome (PCOS). However, little is known about the mechanisms of action of this drug during pregnancy. In the attempt to fill this gap, we performed a prospective longitudinal study providing a detailed examination of glucose and insulin metabolism in pregnant women with PCOS ...

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Effects of Metformin, Metformin Plus Rosiglitazone, and Metformin Plus Lifestyle on Insulin Sensitivity and β-Cell Function in TODAY

OBJECTIVE The Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) trial demonstrated that combination therapy with metformin plus rosiglitazone provided superior durability of glycemic control compared with metformin alone, with significantly lower treatment failure rates (38.6 vs. 51.7%), and metformin plus lifestyle was intermediate. Herein we describe the temporal changes ...

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metformin-letrozole in comparison with metformin-clomiphene citrate in clomiphene-resistance pcos patients undergoing iui

background: polycystic ovary syndrome (pcos) is associated with approximately 75% of women who suffer from infertility due to anovulation. additionally, around 20– 25% of anovulatory women with pcos do not respond at all to clomiphene citrate and are considered to be “clomiphene– resistant”. aromatase inhibitors have been suggested as an alternative treatment to clomiphene as the discrepancy be...

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ژورنال

عنوان ژورنال: Acta Endocrinologica (Bucharest)

سال: 2017

ISSN: 1841-0987,1843-066X

DOI: 10.4183/aeb.2017.84