Conversion of Trichloroacetic Acid to Dichloroacetic Acid in Biological Samples
نویسندگان
چکیده
منابع مشابه
Conversion of trichloroacetic acid to dichloroacetic acid in biological samples.
Trichloroethylene (TCE) has been identified as an environmental contaminant in groundwater. Trichloroacetic acid (TCA), dichloroacetic acid (DCA), chloral hydrate (CH), trichloroethanol (TCOH), and trichloroethanol glucuronide (TCOG) have been identified as metabolites of TCE. Studies have shown that TCA and DCA are toxicologically significant metabolites that can induce liver tumors in B6C3F1 ...
متن کاملDichloroacetic Acid
(IARC, 1995). Since that time, new data have become available, and these have been incorporated into the monograph and taken into consideration in the present evaluation. 1.1.2 Structural and molecular formulae and relative molecular mass C 2 H 2 Cl 2 O 2 Relative molecular mass: 128.94 1.1.3 Chemical and physical properties of the pure substance
متن کاملThe Conversion Kinetics of Tincal to Boric Acid in Nitric Acid Solutions
Pure borax and various boron compounds are produced from the solutions in which tincal is dissolved with various reagents. Economically important boron compounds such as boric acid, borax, boric oxide, and refined hydrated sodium borates and perborates are produced from boron-containing ores. The production of boric acid by using nitric acid from tincal is more advantageous because it evalu...
متن کاملDetection of Ascorbic Acid in Biological Samples by a New Modified Glassy Carbon Electrode
The present work describes the construction of a new modified electrode by casting the appropriate mixture of a metallocene, which has been introduced in the experimental part, as a mediator at the surface of glassy carbon (GC) electrode. The proposed modified GC electrode was used for the determination of ascorbic acid (AA) in phosphate buffer (PB) solution (pH = 4.0). When compared to bare GC...
متن کاملPharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.
Trichloroethylene (TCE) is a well-known carcinogen in rodents and concerns exist regarding its potential carcinogenicity in humans. Oxidative metabolites of TCE, such as dichloroacetic acid (DCA) and trichloroacetic acid (TCA), are thought to be hepatotoxic and carcinogenic in mice. The reactive products of glutathione conjugation, such as S-(1,2-dichlorovinyl)-L-cysteine (DCVC), and S-(1,2-dic...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Analytical Toxicology
سال: 1996
ISSN: 1945-2403,0146-4760
DOI: 10.1093/jat/20.4.236