منابع مشابه
Role of Cytokines in Pathophysiology of Asthma
The worldwide incidence, morbidity and mortality of asthma are increasing dramatically. It is one of the most common disorders encountered in clinical medicine in both children and adults. It affects approximately 5% of the adult population in the western world and its reported incidence is increasing vigorously in many developed nations. A network of a novel mediator known as ‘pleiotropic cyto...
متن کاملCytokines in asthma.
The airway inflammation underlying asthma is regulated by a network of mutually interacting cytokines. The exact functional role of each individual cytokine in the pathogenesis of the disease remains to be fully established. Type 2 T-helper cells are currently considered to play a crucial role in this process. In vivo animal data suggest a sequential involvement of interleukin (IL)-4 and IL-5 i...
متن کاملOccasional review Cytokines in asthma
Cytokines are usually extracellular signalling proteins, usually less than 80 kD in size, and many are glycosylated. They are produced by many diVerent cell types that are involved in cell-to-cell interactions acting through specific receptors on the surface of target cells. Cytokines usually have an eVect on closely adjacent cells and therefore function in a predominantly paracrine fashion, al...
متن کامل[Role of cytokines in pathophysiology of asthma].
The worldwide incidence, morbidity and mortality of asthma are increasing dramatically. It is one of the most common disorders encountered in clinical medicine in both children and adults. It affects approximately 5% of the adult population in the western world and its reported incidence is increasing vigorously in many developed nations. A network of novel mediators known as ‘pleiotropic cytok...
متن کاملSorting out the cytokines of asthma
A sthma is a complex disorder characterized by intermittent, reversible airway obstruction, and by airway hyperresponsiveness and inflammation. Although its cause(s) remain unknown, we now recognize that asthma is a syndrome whose common pathologic expression is inflammation of the airways. The airways of patients with even mild asthma are inflamed, and some data suggest that the severity of th...
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ژورنال
عنوان ژورنال: Thorax
سال: 1993
ISSN: 0040-6376
DOI: 10.1136/thx.48.8.845