Detrimental effect of Bisphenol S in mouse germ cell cyst breakdown and primordial follicle assembly

The female reproductive lifespan is largely determined by the size of primordial follicle pool, which established in early life. Bisphenol S (BPS), frequently present plastic products used daily life, has been demonstrated as an exogenous estrogen-like endocrine disrupting chemical interfering with and systems. However, molecular mechanisms its toxicity remain to be determined. In study, we focused on effect BPS ovarian folliculogenesis mice. Our vivo experiments showed that treatment at 2 10 ?g/kg body weight/day for 3 days induced abnormal germ cell cyst breakdown assembly mouse ovary, further affecting later differentiation reducing oocyte quality. addition, our vitro study could interact estrogen receptors (ERs) induce phosphorylation JNKs, responsible adhesion cysts. Meanwhile, exposure up-regulated Notch signaling pathway increase proliferation granulosa cells precursors. provided new evidence adverse effects reproduction, especially after perinatal exposure, elucidated how it works.