منابع مشابه
Mechanism of Attenuation of Skeletal Muscle Atrophy
D-Myo-inositol 1,2,6-triphosphate (alpha trinositol, AT) has been shown to attenuate muscle atrophy in a murine cachexia model through an increase in protein synthesis and a decrease in degradation. The mechanism of this effect has been investigated in murine myotubes using a range of catabolic stimuli, including proteolysis-inducing factor (PIF), angiotensin II (Ang II), lipopolysaccharide, an...
متن کاملMolecular mechanisms of skeletal muscle atrophy
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متن کاملIL-6-induced skeletal muscle atrophy.
Chronic, low-level elevation of circulating interleukin (IL)-6 is observed in disease states as well as in many outwardly healthy elderly individuals. Increased plasma IL-6 is also observed after intense, prolonged exercise. In the context of skeletal muscle, IL-6 has variously been reported to regulate carbohydrate and lipid metabolism, increase satellite cell proliferation, or cause muscle wa...
متن کاملThe molecular basis of skeletal muscle atrophy.
Skeletal muscle atrophy attributable to muscular inactivity has significant adverse functional consequences. While the initiating physiological event leading to atrophy seems to be the loss of muscle tension and a good deal of the physiology of muscle atrophy has been characterized, little is known about the triggers or the molecular signaling events underlying this process. Decreases in protei...
متن کاملExtracellular Matrix and Gelatinases in Disuse-induced Skeletal Muscle Atrophy
+Liu, X.; Lee, D., Natsuhara K., Kim, H. +University of California, San Francisco, CA, Veterans Affairs Medical Center, San Francisco, CA Senior author: [email protected] INTRODUCTION: Extracellular matrix (ECM) plays a critical role in maintaining normal structure and function of skeletal muscle. Muscle basement membrane serves as an interface between cells and the rest of matrix. It is ...
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ژورنال
عنوان ژورنال: The International Journal of Biochemistry & Cell Biology
سال: 2013
ISSN: 1357-2725
DOI: 10.1016/j.biocel.2013.05.002