Editorial: Cellular Mechanisms of Ototoxicity

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Editorial: Cellular Mechanisms of Ototoxicity

Oregon Hearing Research Center, Oregon Health & Science University, Portland, OR, United States, National Center for Rehabilitative Auditory Research, VA Portland Health Care System, Portland, OR, United States, National Institute on Deafness and Other Communication Disorders, Bethesda, MD, United States, Hearing Center of Excellence, J-9, Defense Health Agency, Joint Base San Antonio, San Anto...

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INTRODUCTION Cisplatin is an effective chemotherapeutic agent commonly used in the treatment of malignant tumours, but ototoxicity is a significant side effect. OBJECTIVES To discuss the mechanisms of cisplatin ototoxicity and subsequent cell death, and to present the results of experimental studies. MATERIAL AND METHODS We conducted a systematic search for data published in national and in...

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Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection

Evidence of significant hearing loss during the early days of use of cisplatin as a chemotherapeutic agent in cancer patients has stimulated research into the causes and treatment of this side effect. It has generally been accepted that hearing loss is produced by excessive generation of reactive oxygen species (ROS) in cell of the cochlea, which led to the development of various antioxidants a...

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Aminoglycosides are commonly prescribed antibiotics with deleterious side effects to the inner ear. Due to their popular application as a result of their potent antimicrobial activities, many efforts have been undertaken to prevent aminoglycoside ototoxicity. Over the years, understanding of the antimicrobial as well as ototoxic mechanisms of aminoglycosides has increased. These mechanisms are ...

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ژورنال

عنوان ژورنال: Frontiers in Cellular Neuroscience

سال: 2018

ISSN: 1662-5102

DOI: 10.3389/fncel.2018.00075