منابع مشابه
Effect of Timing of Electromyostimulation on Denervated Skeletal Muscle Atrophy
Introduction: In this study we evaluated the effect of electromyostimulation (EMS) on myosin heavy chain (MHC) isoform expression in denervated rat muscles to determine the optimal timing for EMS application. Methods: EMS was initiated on post-injury day 1 for the group with denervation receiving immediate EMS (DIEMS) and on post-injury day 15 for the group with denervation receiving delayed EM...
متن کاملInterrelations of myogenic response, progressive atrophy of muscle fibers, and cell death in denervated skeletal muscle.
Little is known concerning the time-course and structural dynamics of reactivation of compensatory myogenesis in denervated muscle, its initiating cellular mechanisms, and the relationship between this process and the progression of postdenervation atrophy. The purpose of this study was to investigate the interrelations between temporal and spatial patterns of the myogenic response in denervate...
متن کاملImplantation of muscle satellite cells overexpressing myogenin improves denervated muscle atrophy in rats
This study evaluated the effect of muscle satellite cells (MSCs) overexpressing myogenin (MyoG) on denervated muscle atrophy. Rat MSCs were isolated and transfected with the MyoG-EGFP plasmid vector GV143. MyoG-transfected MSCs (MTMs) were transplanted into rat gastrocnemius muscles at 1 week after surgical denervation. Controls included injections of untransfected MSCs or the vehicle only. Mus...
متن کاملOverexpression of MyoD Attenuates Denervated Rat Skeletal Muscle Atrophy and Dysfunction
Nerve injury commonly contributes to irreversible functional impairment, reconstruction of the function of muscle is big challenge. In denervated skeletal muscle, therapid expression of MyoD mRNA and protein also occurs during early postdenervation, which suggested that the function of denervation-induced MyoD may be to prevent denervation-induced skeletal muscle atrophy. However, the detail me...
متن کاملRegenerative cell injection in denervated muscle reduces atrophy and enhances recovery following nerve repair.
INTRODUCTION Functional muscle recovery after peripheral nerve injury is far from optimal, partly due to atrophy of the muscle arising from prolonged denervation. We hypothesized that injecting regenerative cells into denervated muscle would reduce this atrophy. METHODS A rat sciatic nerve lesion was performed, and Schwann cells or adipose-derived stem cells, untreated or induced to a "Schwan...
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ژورنال
عنوان ژورنال: BMJ
سال: 1945
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.4423.485