منابع مشابه
Gene expression tomography.
Gene expression tomography, or GET, is a new method to increase the speed of three-dimensional (3-D) gene expression analysis in the brain. The name is evocative of the method's dual foundations in high-throughput gene expression analysis and computerized tomographic image reconstruction, familiar from techniques such as positron emission tomography (PET) and X-ray computerized tomography (CT)....
متن کاملNew views of gene expression in the brain focus on "gene expression tomography".
TOMOGRAPHIC IMAGE RECONSTRUCTION is used in combination with some of the most sophisticated imaging techniques, including ultrasound, X-ray, and positron emission scans, to visualize anatomic structures in much greater detail than can typically be achieved using conventional techniques. Positron emission tomography (PET), for example, computationally reassembles full three-dimensional (3-D) ima...
متن کاملPositron-emission tomography reporter gene expression imaging in rat myocardium.
BACKGROUND This study examines the quantitative accuracy, detection sensitivity, and time course of imaging the expression of a mutant herpes simplex type-1 virus thymidine kinase (HSV1-sr39tk) PET reporter gene in rat myocardium by using the PET reporter probe 9-(4-[18F]-Fluoro-3-Hydroxymethylbutyl)-Guanine ([18F]-FHBG) and a small-animal PET (microPET). METHODS AND RESULTS In 40 rats, adeno...
متن کاملMulti-Scale Molecular Photoacoustic Tomography of Gene Expression
Photoacoustic tomography (PAT) is a molecular imaging technology. Unlike conventional reporter gene imaging, which is usually based on fluorescence, photoacoustic reporter gene imaging relies only on optical absorption. This work demonstrates several key merits of PAT using lacZ, one of the most widely used reporter genes in biology. We show that the expression of lacZ can be imaged by PAT as d...
متن کاملImaging pulmonary gene expression with positron emission tomography.
We evaluated positron emission tomographic imaging of pulmonary transgene expression, using an enhanced mutant herpes simplex virus-1 thymidine kinase as the reporter gene, in the lungs of normal rats. Sixteen rats were studied 3 days after an intratracheal administration of 5 x 10(9) to 1 x 10(11) viral particles of a replication-incompetent adenovirus containing a fusion gene of the mutant ki...
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ژورنال
عنوان ژورنال: Physiological Genomics
سال: 2002
ISSN: 1094-8341,1531-2267
DOI: 10.1152/physiolgenomics.00090.2001