Hydrodynamic Gene Delivery and Its Applications in Pharmaceutical Research
نویسندگان
چکیده
منابع مشابه
Animal Models for Hydrodynamic Gene Delivery
Hydrodynamic gene delivery (HGD) is an established method of the last decade where macromolecules, non-normally permeable to cell membrane, are delivered intracellular. The basic principle is that a large volume of solution, containing genes or oligonucleotides, RNA, proteins or other compounds, is infused rapidly in circulation to permit the entrance of these substances to parenchymal cells. E...
متن کاملArtificial Neural Network in Drug Delivery and Pharmaceutical Research
Artificial neural networks (ANNs) technology models the pattern recognition capabilities of the neural networks of the brain. Similarly to a single neuron in the brain, artificial neuron unit receives inputs from many external sources, processes them, and makes decisions. Interestingly, ANN simulates the biological nervous system and draws on analogues of adaptive biological neurons. ANNs do no...
متن کاملNumerical Hydrodynamic Performance of the Stepped Planing Craft and Its Step Height Effect (RESEARCH NOTE)
One of the most efficient methods of reducing drag on planing craft is the use of transverse step on the bottom of a hull. Applying steps on the hull reduces the contact area with water and as a result, it reduces drag of the craft. Planing craft are able to have one or two transverse steps. In this paper, numerical hydrodynamic performance of the stepped planing craft and its step height effec...
متن کاملImage-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions
Hydrodynamics-based delivery has been used as an experimental tool to express transgene in small animals. This in vivo gene transfer method is useful for functional analysis of genetic elements, therapeutic effect of oligonucleotides, and cancer cells to establish the metastatic cancer animal model for experimental research. Recent progress in the development of image-guided procedure for hydro...
متن کاملSafety Assessment of Liver-Targeted Hydrodynamic Gene Delivery in Dogs
Evidence in support of safety of a gene delivery procedure is essential toward gene therapy. Previous studies using the hydrodynamics-based procedure primarily focus on gene delivery efficiency or gene function analysis in mice. The current study focuses on an assessment of the safety of computer-controlled and liver-targeted hydrodynamic gene delivery in dogs as the first step toward hydrodyna...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pharmaceutical Research
سال: 2010
ISSN: 0724-8741,1573-904X
DOI: 10.1007/s11095-010-0338-9