منابع مشابه
Hypoxic, Ischemic, and Reperfusion Injury to Liver
HEPATIC OXYGEN METABOLISM 258 VULNERABILITY OF LIVER TO HYPOXIC AND ISCHEMIC INJURY 259 CELLULAR CHANGES IN HYPOXIA 259 ADENOSINE TRIPHOSPHATE DEPLETION AND HYPOXIC HEPATOCELLULAR NECROSIS 260 PROTECTION BY ACIDOTIC PH AGAINST HYPOXIC KILLING OF LIVER CELLS 261 THE PH PARADOX IN EARLY ISCHEMIA/REPERFUSION INJURY 262 THE MITOCHONDRIAL PERMEABILITY TRANSITION IN REPERFUSION INJURY 262 REACTIVE OX...
متن کاملHypoxic liver injury and cholestasis in critically ill patients.
PURPOSE OF REVIEW Liver dysfunction frequently complicates the clinical picture of critical illness and leads to increased morbidity and mortality. The purpose of this review is to characterize the most frequent patterns of liver dysfunction at the intensive care unit, cholestasis and hypoxic liver injury (HLI), and to illustrate its clinical impact on outcome in critically ill patients. RECE...
متن کاملHypoxic-Ischemic Brain Injury in Piglets
Background and Purpose: The excitatory amino acid inhibitor MK-801 has been shown in many animals species to protect against hypoxic-ischemic brain injury. We sought to determine whether hypoxic-ischemic injury to the newborn pig's brain could be prevented by the use of MK-801. Methods: Hypoxic-ischemic injury to the brain was induced in forty 0-3-day-old piglets. They were randomized to receiv...
متن کاملMitochondrial Proteostatic Collapse Leads to Hypoxic Injury
Hypoxic injury is a key pathological event in a variety of diseases. Despite the clinical importance of hypoxia, modulation of hypoxic injury mechanisms for therapeutic benefit has not been achieved, suggesting that critical features of hypoxic injury have not been identified or fully understood. Because mitochondria are the main respiratory organelles of the cell, they have been the focus of m...
متن کاملAcute kidney injury with hypoxic respiratory failure.
A 27-year-old Caucasian man was transferred from a remote clinic with acute kidney injury for the prior 7-10 days preceded by gastroenteritis. His kidney biopsy showed non-specific mesangiopathic glomerular changes, minimal tubulointerstitial disease without sclerosis, crescents, nor evidence of vasculitis. On his third hospital day, he developed acute hypoxic respiratory failure requiring intu...
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ژورنال
عنوان ژورنال: Mayo Clinic Proceedings
سال: 2006
ISSN: 0025-6196
DOI: 10.4065/81.9.1232