IL-4 Knock Out Mice Display Anxiety-Like Behavior
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چکیده
منابع مشابه
Hmga1/Hmga2 double knock-out mice display a “superpygmy” phenotype
The HMGA1 and HMGA2 genes code for proteins belonging to the High Mobility Group A family. Several genes are negatively or positively regulated by both these proteins, but a number of genes are specifically regulated by only one of them. Indeed, knock-out of the Hmga1 and Hmga2 genes leads to different phenotypes: cardiac hypertrophy and type 2 diabetes in the former case, and a large reduction...
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Beckman et al. (1) reported altered monoaminergic systems and depressive-like behaviors in a line of mice lacking the cellular prion protein PrP (congenic B10.129-Prnp mice). These mice were derived from gene-targeted 129/Ola embryonic stem cells and were subsequently crossed to C57BL/10SnJ mice. Consequently, the genomic region of B10.129-Prnp mice flanking the targeted Prnp locus contains a s...
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TRH is a neuropeptide with a variety of hormonal and neurotransmitter/neuromodulator functions. In particular, TRH has pronounced acute antidepressant effects in both humans and animals and has been implicated in the mediation of the effects of other antidepressive therapies. Two G protein-coupled receptors, TRH receptor 1 (TRH-R1) and TRH-R2, have been identified. Here we report the generation...
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Previous studies have suggested that oxytocin (OT) may be anxiolytic in female laboratory rats and mice. The elevated plus-maze was used to compare anxiety-related behaviors of OT-deficient (OT-/-) and wild-type (OT+/+) mice. Female OT-/- mice displayed increased anxiety-related behavior compared with OT+/+ mice. The percentage of entries (P < 0.0002) and time spent (P < 0.003) in the open arms...
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Local purinergic signals modulate renal tubular transport. Acute activation of renal epithelial P2 receptors causes inhibition of epithelial transport and thus, should favor increased water and salt excretion by the kidney. So far only a few studies have addressed the effects of extracellular nucleotides on ion transport in the thick ascending limb (TAL). In the medullary thick ascending limb (...
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ژورنال
عنوان ژورنال: Behavior Genetics
سال: 2015
ISSN: 0001-8244,1573-3297
DOI: 10.1007/s10519-015-9714-x