Inhibition of DNA replication by an anti-PCNA aptamer/PCNA complex
نویسندگان
چکیده
منابع مشابه
Inhibition of DNA replication by an anti-PCNA aptamer/PCNA complex
Proliferating cell nuclear antigen (PCNA) is a multifunctional protein present in the nuclei of eukaryotic cells that plays an important role as a component of the DNA replication machinery, as well as DNA repair systems. PCNA was recently proposed as a potential non-oncogenic target for anti-cancer therapy. In this study, using the Systematic Evolution of Ligands by EXponential enrichment (SEL...
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Replication of the entire genome during S-phase is one of the most important cell cycle events and requires the coordinated activity of a multitude of different enzymes. Proliferating cell nuclear antigen (PCNA) interacts directly and indirectly with most of these proteins and thereby plays a leading part in the coordination of the replication process. PCNA is the processivity factor for the re...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2017
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkx1184