Inhibition of the NKp44-PCNA Immune Checkpoint Using a mAb to PCNA
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چکیده
منابع مشابه
Inhibition of DNA replication by an anti-PCNA aptamer/PCNA complex
Proliferating cell nuclear antigen (PCNA) is a multifunctional protein present in the nuclei of eukaryotic cells that plays an important role as a component of the DNA replication machinery, as well as DNA repair systems. PCNA was recently proposed as a potential non-oncogenic target for anti-cancer therapy. In this study, using the Systematic Evolution of Ligands by EXponential enrichment (SEL...
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PCNA (proliferating-cell nuclear antigen) is a ring-shaped protein that encircles duplex DNA and plays an essential role in many DNA metabolic processes. The PCNA protein interacts with a large number of cellular factors and modulates their enzymatic activities. In the present paper, we summarize the structures, functions and interactions of the archaeal PCNA proteins.
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The eukaryotic polymerase processivity factor, PCNA, interacts with cell cycle regulatory proteins such as p21(WAF1/Cip1) and Gadd45, as well as with proteins involved in the mechanics of DNA repair and replication. A conserved PCNA-binding motif is found in a subset of PCNA-interacting proteins, including p21, suggesting that the regulation of these interactions is important for the co-ordinat...
متن کاملEmbryonic PCNA: a missing link?
PCNA, the processivity factor of the eukaryotic replicative DNA polymerase [1], is the functional homolpgue of the [3 subunit of Escherichia coli DNA polymerase III holo-enzyme [2,3]. Biochemical studies have shown that the E. coli 3 subunit acts as a sliding clamp on duplex DNA; it has a ring shape that encircles DNA and it binds directly to Pol III, tethering it to DNA to achieve highly proce...
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Histone modifications impact various processes. In examining histone acetyltranferase HAT3 of Leishmania donovani, we find elimination of HAT3 causes decreased cell viability due to defects in histone deposition, and aberrant cell cycle progression pattern. HAT3 associates with proliferating cell nuclear antigen (PCNA), helping load PCNA onto chromatin in proliferating cells. HAT3-nulls show he...
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ژورنال
عنوان ژورنال: Cancer Immunology Research
سال: 2019
ISSN: 2326-6066,2326-6074
DOI: 10.1158/2326-6066.cir-19-0023