Inhibitor of apoptosis proteins and apoptosis

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Inhibitor of apoptosis proteins and apoptosis.

Apoptosis is a physiological cell death process that plays a critical role in development, homeostasis, and immune defense of multicellular animals. Inhibitor of apoptosis proteins (IAPs) constitute a family of proteins that possess between one and three baculovirus IAP repeats. Some of them also have a really interesting new gene finger domain, and can prevent cell death by binding and inhibit...

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Osthole induces lung cancer cell apoptosis through inhibition of inhibitor of apoptosis family proteins

In the present study, we investigated the effects and mechanisms of Osthole on the apoptosis of non-small cell lung cancer (NSCLC) cells and its synergistic effect with Embelin. Our results revealed that treatment with both Osthole and Embelin inhibited cell proliferation. Notably, combination treatment of Osthole and Embelin inhibited cell proliferation more significantly compared with monothe...

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Down-regulation of inhibitor of apoptosis proteins by deguelin selectively induces apoptosis in breast cancer cells.

The identification of differentially regulated apoptotic signals in normal and tumor cells allows the development of cancer cell-selective therapies. Increasing evidence shows that the inhibitor of apoptosis (IAP) proteins survivin and XIAP are highly expressed in tumor cells but are absent or have very low levels of expression in normal adult tissues. We found that inhibiting AKT activity with...

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Elevated expression of inhibitor of apoptosis proteins in prostate cancer.

PURPOSE Inhibitor of apoptosis (IAP) family proteins are suppressors of apoptosis that have been implicated in apoptosis resistance in some cancers. Their expression and relevance to the prognosis of prostate cancer were investigated. EXPERIMENTAL DESIGN The expression of four members of the IAP family (cellular inhibitor of apoptosis protein 1, cellular inhibitor of apoptosis protein 2, X ch...

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Inhibitor of apoptosis proteins as novel targets in inflammatory processes.

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ژورنال

عنوان ژورنال: Acta Biochimica et Biophysica Sinica

سال: 2008

ISSN: 1672-9145,1745-7270

DOI: 10.1111/j.1745-7270.2008.00407.x