Insulin and intestinal epithelial cell proliferation
نویسندگان
چکیده
منابع مشابه
Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2.
Sphingosine-1 phosphate (S1P) is a potent bioactive lipid mediator that acts both as an intracellular signaling molecule and a natural ligand of five different G protein-coupled receptors (GPCRs), S1PR1-5. The level of S1P in intestinal tissue is abundant. Previous studies have reported that S1P protects intestinal epithelial cell from apoptosis by activating the ERK and Akt signaling pathways....
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Although the presence of subepithelial intestinal fibroblasts has been well recognized, the effects of fibroblasts on intestinal epithelial cell (IEC) growth are incompletely understood. In vitro studies were undertaken to evaluate the effects of fibroblasts on the proliferation of model IEC lines. IECs (Caco-2, T84, and IEC-6) were grown alone or in the presence of human intestinal (CCD-18), l...
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1 SHOULD first like to thank you for inviting me to be the Robert Campbell Orator on this occasion. For anyone in the field of medical science it is a great honour to give this lecture, for a Queen's graduate it is a very special honour, but for a Queen's graduate who is also an exile, it is not only an honour but a very welcome opportunity to come back again to this medical school. Although my...
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Intestinal cell kinase (ICK), originally cloned from the intestine and expressed in the intestinal crypt epithelium, is a highly conserved serine/threonine protein kinase that is similar to mitogen-activated protein kinases (MAPKs) in the catalytic domain and requires dual phosphorylation within a MAPK-like TDY motif for full activation. Despite these similarities to MAPKs, the biological funct...
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ژورنال
عنوان ژورنال: Experimental Physiology
سال: 1993
ISSN: 0958-0670
DOI: 10.1113/expphysiol.1993.sp003717