Integration of biomimicry and nanotechnology for significantly improved detection of circulating tumor cells (CTCs)
نویسندگان
چکیده
منابع مشابه
Nanotechnology for the detection and kill of circulating tumor cells
Circulating tumor cells (CTCs) represent a surrogate biomarker of hematogenous metastases and thus could be considered as a 'liquid biopsy' which reveals metastasis in action. But it is absolutely a challenge to detect CTCs due to their extreme rarity. At present, the most common principle is to take advantage of the epithelial surface markers of CTCs which attach to a specific antibody. Antibo...
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BACKGROUND Detection of CTCs is a poor prognostic factor for many cancer types; however, their very low frequency represents an obstacle for their detection. The objective of the current study was to compare the performance of commonly used methods for CTCs isolation. METHODS The evaluated methods using spiking experiments of MCF7, SKBR3 and MDA MB-231 breast cancer cell lines were (i) ficoll...
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Cancer stem cells with stem-cell properties are regarded as tumor initiating cells. Sharing stem-cell properties, circulating tumor cells (CTCs) are responsible for the development of metastasis, which significant affects CTC analysis in clinical practice. Due to their extremely low occurrence in blood, however, it is challenging to enumerate and analyze CTCs. Nanotechnology is able to address ...
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Circulating tumor cells (CTC) are cells that have detached from primary tumors and circulate in the bloodstream where they are carried to other organs, leading to seeding of new tumors and metastases. CTC have been known to exist in the bloodstream for more than a century. With recent progress in the area of micro- and nanotechnology, it has been possible to adopt new approaches in CTC research...
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Objective(s): In the developed countries, one of the leading causes of death is cancer. Cancer cells with their unique and destructive characteristics impose high costs on communities. Methods: In this study, we will review the latest cancer researches an...
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ژورنال
عنوان ژورنال: Advanced Drug Delivery Reviews
سال: 2018
ISSN: 0169-409X
DOI: 10.1016/j.addr.2017.12.005