Isolated Hepatic Perfusion with 200 mg Melphalan for Advanced Noncolorectal Liver Metastases
نویسندگان
چکیده
منابع مشابه
Isolated hepatic melphalan perfusion of colorectal liver metastases: outcome and prognostic factors in 154 patients.
BACKGROUND The aim of this study was to identify prognostic factors for local and systemic failure after isolated hepatic perfusion (IHP) with 200 mg melphalan in patients with colorectal liver metastases. PATIENTS AND METHODS Hundred and fifty-four patients were selected for IHP and underwent laparotomy. Patients were monitored for response, toxicity and survival. Univariate and multivariate...
متن کاملHyperthermic isolated hepatic perfusion using melphalan for patients with ocular melanoma metastatic to liver.
PURPOSE Liver metastases are the sole or life-limiting component of disease in the majority of patients with ocular melanoma who recur. Because median survival after diagnosis of liver metastases is short and no satisfactory treatment options exist, we have conducted clinical trials evaluating isolated hepatic perfusion (IHP) for patients afflicted with this condition. EXPERIMENTAL DESIGN Twe...
متن کاملIsolated limb perfusion with melphalan for melanoma.
Isolated limb perfusion with melphalan is a well-established and effective treatment for inoperable melanoma metastases of the extremities, with an overall response rate of 80% and a complete response rate of 54%. The surgical technique is complex and serious morbidity can occur, but with attention to detail major side effects can be kept to a minimum. This article reviews the technique, result...
متن کاملIsolated hepatic perfusion with high-dose melphalan for the treatment of colorectal metastasis confined to the liver.
BACKGROUND Isolated hepatic perfusion (IHP) involves complete vascular isolation of the liver to allow treatment with doses that would be toxic if delivered systemically. A phase II study of IHP in patients with colorectal metastases confined to the liver was performed. METHODS Seventy-three patients with irresectable colorectal metastases underwent IHP with high-dose melphalan (200 mg) for 1...
متن کاملSystemic toxicity after isolated limb perfusion with melphalan for melanoma.
Systemic exposure to melphalan is minimized during isolated limb perfusion (ILP) by isolating a limb from the rest of the body. Consequently, there should be no toxicity to vital organs. At present systemic toxicity after ILP has not been studied in detail. Therefore, the incidence, nature and risk factors of systemic toxicity was retrospectively studied in 368 patients who underwent a single I...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of Surgical Oncology
سال: 2008
ISSN: 1068-9265,1534-4681
DOI: 10.1245/s10434-008-9881-6