JAK2/STAT3 Inhibition Attenuates Noise-Induced Hearing Loss


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JAK2/STAT3 Inhibition Attenuates Noise-Induced Hearing Loss

Signal transducers and activators of transcription 3 (STAT3) is a stress responsive transcription factor that plays a key role in oxidative stress-mediated tissue injury. As reactive oxygen species (ROS) are a known source of damage to tissues of the inner ear following loud sound exposure, we examined the role of the Janus kinase 2 (JAK2)/STAT3 signaling pathway in noise induce hearing loss us...

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Inhibition of cyclooxygenase-2 by NS398 attenuates noise-induced hearing loss in mice.

Noise-induced hearing loss (NIHL) is an important occupational disorder. However, the molecular mechanisms underlying NIHL have not been fully clarified; therefore, the condition lacks effective therapeutic methods. Cyclooxygenase-2 (Cox-2) is an inducible enzyme involved in the synthesis of prostaglandins, and has been implicated in many pathophysiological events, such as oxidative stress and ...

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noise-induced hearing loss: prevention is possible

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Noise-Induced hearing loss among professional musicians

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عنوان ژورنال: PLoS ONE

سال: 2014

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0108276