Janus-Faced Sestrin2 Controls ROS and MTOR Signalling Through Two Separate Functional Domains

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

Sestrins are stress-inducible metabolic regulators with two seemingly unrelated but physiologically important functions: reduction of reactive oxygen species (ROS) and inhibition of the mechanistic target of rapamycin complex 1 (mTORC1). How Sestrins fulfil this dual role has remained elusive so far. Here we report the crystal structure of human Sestrin2 (hSesn2), and show that hSesn2 is twofol...

The Janus Faced

This paper briefl y discusses the history of the standard information retrieval evaluation criteria, measures and methods, and why they are unsuitable for the evaluation of interactive information retrieval. A new framework for evaluation of interactive information retrieval is proposed, based on the criterion of usefulness.

Usa1 Protein Facilitates Substrate Ubiquitylation through Two Separate Domains

BACKGROUND Defects in protein folding are recognized as the root of many neurodegenerative disorders. In the endoplasmic reticulum (ER), secretory proteins are subjected to a stringent quality control process to eliminate misfolded proteins by the ER-associated degradation (ERAD) pathway. A novel ERAD component Usa1 was recently identified. However, the specific role of Usa1 in ERAD remains obs...

Hungary : The Janus - faced Success

This paper offers a broad overview of the Hungarian development strategy over the past two decades. Combining historical and functional analysis, some major strengths and weaknesses are identified, with special emphasis on the country’s open-door policies and the role played by the European Union. The paper investigates why the impetus of institutional and financial integration was lost by abou...

Separate Functional Domains of Human MD - 2