منابع مشابه
Knockout! Knockout! Who’s Not There?
The deeper we look at human genomes, the more unexpected things we find. And increasingly we are surprised by what each of us lacks. In particular, in recent years we have learned that naturally occurring human gene knockouts are prevalent. The results of the Exome Aggregation Consortium (ExAC) now paint a rich and detailed picture of gene redundancy and essentiality in humans (Lek et al., 2016...
متن کاملA knockout may not always be a knockout.
To the Editor: In a recent issue of Circulation, Hoorntje et al1 presented data on a family with a duplication in exon 4 of HERG. A consanguineous marriage resulted in 2 homozygous offspring: one died before birth and the other had a severe cardiac phenotype characterized by arrhythmias and conduction defects. The importance of these findings regarding the role of HERG in the heart is clear. Th...
متن کاملEfficient Simulation of a Random Knockout Tournament
We consider the problem of using simulation to efficiently estimate the win probabilities for participants in a general random knockout tournament. Both of our proposed estimators, one based on the notion of “observed survivals” and the other based on conditional expectation and post-stratification, are highly effective in terms of variance reduction when compared to the raw simulation estimato...
متن کاملKnockout Corner : Knockout mice for monoamine oxidase A
A line of transgenic mice was isolated in which transgene integration had caused a deletion in the gene encoding monoamine oxidase A, an enzyme that degrades serotonin and norepinephrine. This has provided an animal model of MAOA deficiency in humans, a condition characterized by borderline mental retardation and impulsive aggression. Received 13 June 1999 ; Reviewed 14 June 1999 ; Accepted 16 ...
متن کاملKnockout Corner: Knockout mice for monoamine oxidase A.
A line of transgenic mice was isolated in which transgene integration had caused a deletion in the gene encoding monoamine oxidase A, an enzyme that degrades serotonin and norepinephrine. This has provided an animal model of MAOA deficiency in humans, a condition characterized by borderline mental retardation and impulsive aggression.
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ژورنال
عنوان ژورنال: Cell
سال: 2016
ISSN: 0092-8674
DOI: 10.1016/j.cell.2016.09.040