Lack of Functionally Active Melan-A26–35-Specific T Cells in the Blood of HLA-A2+ Vitiligo Patients

Cytotoxic T lymphocytes from HLA-A2 transgenic mice specific for HLA-A2 expressed on human cells

CTL clones were derived from HLA-A2.1 transgenic mice by immunization with a human cell expressing HLA-A2.1. None of these clones lysed murine transfectants, and only 3 of 23 lysed monkey transfectants expressing HLA-A2. In contrast, all of these clones lysed a wide variety of human cells expressing HLA-A2.1. These results demonstrate the existence of species-specific epitopes on the HLA-A2.1 m...

Impact of orthologous melan-A peptide immunizations on the anti-self melan-A/HLA-A2 T cell cross-reactivity.

In HLA-A2 individuals, the CD8 T cell response against the differentiation Ag Melan-A is mainly directed toward the peptide Melan-A26-35. The murine Melan-A24-33 sequence encodes a peptide that is identical with the human Melan-A26-35 decamer, except for a Thr-to-Ile substitution at the penultimate position. Here, we show that the murine Melan-A24-33 is naturally processed and presented by HLA-...

Melan-A/HLA-A2 T Cell Cross-Reactivity Immunizations on the Anti-Self Impact of Orthologous Melan-A Peptide

Deciphering the unusual HLA-A2/Melan-A/MART-1-specific TCR repertoire in humans.

The Melan-A/MART-1(26-35) antigenic peptide is one of the best studied human tumor-associated antigens. It is expressed in healthy melanocytes and malignant melanoma and is recognized by CD8(+) T cells in the context of the MHC class I molecule HLA-A*0201. While an unusually large repertoire of CD8(+) T cells specific for this antigen has been documented, the reasons for its generation have rem...

strategies applied in translation of culture-specific items in translation of the i. r. i. constitution &the civil code (from persian into english(

این تحقیق به بررسی استراتژیهای بکاررفته توسط مترجمین مختلف در ترجمه واژه های فرهنگی خاص در ترجمه فارسی به انگلیسی قانون مدنی و قانون اساسی جمهوری اسلامی ایران میپردازد.این تحقیق بر اساس نظریه پیتر نیومارک صرت گرفته است. در این تحفیق واژه های فرهنگی خاص اقتباس شده و پس از مقایسه با متن مبدا به بررسی انها پرداخته می شود.در قسمت ضمائم تحقیق واژه نامه ای برای اشنایی خوانندگان با لغات و اصطلاحات حقو...