Liver cell adenoma and liver cell adenomatosis

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Regarding 'Liver cell adenoma and liver cell adenomatosis' by Ludger Barthelmes and Iain S. Tait.

We read with great interest the recent article by Barthelmes and Tait (HPB 2005;7:186 /196). The impact of the diagnosis ‘liver cell adenoma’ on the life of a young female patient is enormous. Conservative management of liver cell adenoma frequently implies cessation of oral contraceptives, regular follow-up including radiological imaging, and negative advice regarding pregnancy. Surgical treat...

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LIVER DISEASE INK4a-ARF alterations in liver cell adenoma

Background: The INK4a-ARF (CDKN2A) locus on chromosome 9p21 encodes two tumour suppressor proteins, p16 and p14, whose functions are inactivated in many human cancers. Aims: To evaluate p14 and p16 alterations in liver cell adenoma. Methods: After microdissection, DNA from 25 liver cell adenomas and corresponding normal liver tissue were analysed for INK4-ARF inactivation by DNA sequence analys...

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INK4a-ARF alterations in liver cell adenoma.

BACKGROUND The INK4a-ARF (CDKN2A) locus on chromosome 9p21 encodes two tumour suppressor proteins, p16(INK4a) and p14(ARF), whose functions are inactivated in many human cancers. AIMS To evaluate p14(ARF) and p16(INK4a) alterations in liver cell adenoma. METHODS After microdissection, DNA from 25 liver cell adenomas and corresponding normal liver tissue were analysed for INK4-ARF inactivati...

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Surgical strategies for liver cell adenoma

Liver cell adenomas (LCA) are benign tumors that occur primarily in women with a history of oral contraceptive use. While rare, LCA are clinically important because of their propensity for sudden, unpredictable hemorhage or malignant transformation. Differentiation from focal nodular hyperplasia or hepatocellular carcinoma may be difficult even with sophisticated imaging modalities. Current man...

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Hepatic adenomatosis in liver cirrhosis

Hepatocellular adenoma (HCA) is a benign liver tumor most frequently occurring in women using oral contraception. HCA develops in normal or nearly normal livers and is extremely rare in cirrhosis. The authors present magnetic resonance imaging and histopathologic findings in a 57-year-old man with liver cirrhosis and hepatic adenomatosis. As the differentiation between HCA and hepatocellular ca...

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ژورنال

عنوان ژورنال: HPB

سال: 2005

ISSN: 1365-182X

DOI: 10.1080/13651820510028954