LIVER INJURY, LIVER PROTECTION, AND SULFUR METABOLISM

Liver Injury, Liver Protection, and Sulfur Metabolism

Protein-depleted dogs are very susceptible to injurious agents-in particular, chloroform. Methionine given shortly before chloroform anesthesia will give complete protection against chloroform. Methionine (or cysteine plus choline) given 3 or 4 hours after chloroform anesthesia will give significant protection against the liver injury of chloroform anesthesia. Methionine given more than 4 hours...

Bile Salt Metabolism. Viii. Liver Injury and Liver Stimulation

Imatinib metabolism and disposition in isolated rat perfused liver

Imatinib is an orally administered tyrosine kinase inhibitor which inhibits the Bcr-Abl protein-tyrosine kinase with high selectivity. Imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. The metabolism of imatinib is mediated by the cytochrome P450 (CYP) isoenzymes in the liver and gut wall. CGP74588 is a major active metabolite of ima...

Immunomodulation and liver protection of Yinchenhao decoction against concanavalin A-induced chronic liver injury in mice.

OBJECTIVE This study investigated the immunoregulatory and protective roles of Yinchenhao decoction, a compound of Chinese herbal medicine, in a mouse model of concanavalin A (ConA)-induced chronic liver injury. METHODS Female BalB/c mice were randomly divided into 4 groups: normal control, ConA model, ConA model treated with Yinchenhao decoction (400 mg/kg, orally), and ConA model treated wi...

Experimental injury and sulfur amino acid metabolism.

It has been reported that methionine and cystine are capable of accelerating the healing rate of wounds in injured rats to the same extent when present in the diet in equivalent amounts (1). This response was elicited in both the presence and the absence of dietary protein (2). Lysine, tryptophan, and valine do not appear to alter the healing process to a significant degree (3). Because methion...