منابع مشابه
Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) can progress from simple steatosis (i.e., nonalcoholic fatty liver [NAFL]) to nonalcoholic steatohepatitis (NASH), cirrhosis, and cancer. Currently, the driver for this progression is not fully understood; in particular, it is not known how NAFLD and its early progression affects the distribution of lipids in the liver, producing lipotoxicity and inflamm...
متن کاملA theoretical approach to zonation in a bioartificial liver
Bioartificial livers have yet to gain clinical acceptance. In a previous study, a theoretical model was utilized to create operating region charts that graphically illustrated viable bioartificial liver configurations. On this basis a rationale for the choice of operating and design parameters for the device was created. The concept is extended here to include aspects of liver zonation for furt...
متن کاملMetabolic zonation of the liver: The oxygen gradient revisited
The liver has a multitude of functions which are necessary to maintain whole body homeostasis. This requires that various metabolic pathways can run in parallel in the most efficient manner and that futile cycles are kept to a minimum. To a large extent this is achieved due to a functional specialization of the liver parenchyma known as metabolic zonation which is often lost in liver diseases. ...
متن کاملUnderstanding the Role of Liver Zonation in Toxin Elimination
Using game theory and reinforcement learning, we created and analyzed generalized agent-based and compartmental models of hepatic toxin elimination processes to explore plausible causes of hepatic functional zonation. We considered a general situation in which a group of protective agents (analogous to liver cells) cooperate and self-organize their efforts to minimize optimally the negative eff...
متن کاملFlexibility of zonation of fatty acid oxidation in rat liver.
Periportal and perivenous hepatocytes were isolated from rats subjected to different treatments that induce (starvation, cold exposure) or depress (refeeding after starvation) hepatic fatty acid oxidation. These experiments were designed to determine factors that may be involved in creating and maintaining the asymmetrical distribution of this metabolic pathway in the acinus of the liver. The u...
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ژورنال
عنوان ژورنال: Journal of Hepatology
سال: 2021
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2020.09.003