Local Reactions after Diphtheria-tetanus-acellular Pertussis Vaccines in Mice


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Pyrexia after diphtheria/tetanus/pertussis and diphtheria/tetanus vaccines.

The temperatures of 587 children were taken before and after diphtheria/tetanus/pertussis (DTP) or diphtheria/tetanus (DT) vaccine. Only slight temperature increases were found but these were notably more frequent after plain than adsorbed DTP vaccine preparations and the frequency increased with each successive dose.

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Adverse event reports after tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccines in pregnant women.

OBJECTIVE We sought to characterize reports to the Vaccine Adverse Event Reporting System (VAERS) of pregnant women who received tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap). STUDY DESIGN We searched VAERS for reports of pregnant women who received Tdap from Jan. 1, 2005, through June 30, 2010. We conducted a clinical review of reports and available medica...

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Extensive swelling after booster doses of acellular pertussis-tetanus-diphtheria vaccines.

BACKGROUND Diphtheria and tetanus toxoid combined with acellular pertussis (DTaP) vaccines are less reactogenic than diphtheria and tetanus toxoid combined with whole cell pertussis (DTwP) vaccines. However, local reactions increase in rate and severity with each successive DTaP dose, and swelling of the entire injected limb has been reported after booster doses. METHODS We reviewed reports o...

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Quality control of diphtheria tetanus acellular pertussis combined (DTaP) vaccines in Japan.

Diphtheria tetanus acellular pertussis combined (DTaP) vaccines have been successfully used in Japan by controlling their potencies and toxicities with animal models. In accordance with the recent practical introduction of DTaP vaccines of various formulations, a question has been raised in other nations as to the efficacy of a quality control system based on animal tests and standard preparati...

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Estimating the Effectiveness of Tetanus-Diphtheria-Acellular Pertussis Vaccine

TO THE EDITOR—We read with interest Koepke et al’s analysis [1] of Wisconsin Immunization Registry (WIR) and pertussis surveillance databases to determine effectiveness of tetanus-diphtheria-acellular pertussis (Tdap) vaccines. We are familiar with the challenges involved in using such data sources to evaluate the performance of pertussis vaccines, as we have been collaborating since 2008 in a ...

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عنوان ژورنال: Journal of the Japanese Association for Infectious Diseases

سال: 2006

ISSN: 1884-569X,0387-5911

DOI: 10.11150/kansenshogakuzasshi1970.80.108