Lung hyperinflation, perception of bronchoconstriction and airway hyperresponsiveness

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Lung hyperinflation, perception of bronchoconstriction and airway hyperresponsiveness.

PURPOSE To compare the influence of underlying airway inflammation and lung hyperinflation on dyspnea during induced bronchoconstriction in subjects with mild asthma (or asymptomatic airway hyperresponsiveness (AAHR). METHODS Fourteen mild asthmatic and 14 AAHR subjects had methacholine and 5'-adenosine monophosphate (AMP) challenges, and induced sputum analysis. Changes in inspiratory capaci...

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Lung hyperinflation in airway obstruction.

*Dept di Science Motorie, University of Genova, I-16132 Genova, Italy. +Division de Pneumologie, Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland. Since the early studies with inert gas dilution techniques, it has been known that residual volume and functional residual capacity are increased in patients with pulmonary emphysema [1] or acute asthma [2]. These findings were...

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Dynamic hyperinflation during bronchoconstriction in asthma: implications for symptom perception.

OBJECTIVE The objective of this study was to examine the relationship between respiratory symptom intensity and quality and dynamic lung hyperinflation (DH) during induced bronchoconstriction in asthma. PATIENTS AND METHODS Subjects with asthma (n = 116) underwent baseline spirometry and lung volume measurement followed by high-dose methacholine challenge testing (MCT) [maximum decrease in FE...

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On the causes of lung hyperinflation during bronchoconstriction.

Airway obstruction in asthma and chronic obstructive pulmonary disease (COPD) is often associated with lung hyperinflation. In this review, we examine the mechanisms that may cause functional residual capacity (FRC), residual volume (RV) and total lung capacity (TLC) to increase during acute and chronic airway obstruction. Normally, FRC at rest is determined by the static characteristics of the...

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Lung hyperinflation and flow limitation in chronic airway obstruction.

We reasoned that if flow limitation plays an important role in lung hyperinflation, then bronchodilatation should be associated with a decrease of functional residual capacity (FRC) only in subjects breathing under conditions of flow limitation. This hypothesis was tested in 33 subjects with chronic airway narrowing due to asthma or chronic obstructive pulmonary disease (COPD). Flow limitation ...

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ژورنال

عنوان ژورنال: Clinical & Investigative Medicine

سال: 2007

ISSN: 1488-2353

DOI: 10.25011/cim.v30i1.443