Matrix‐mediated mechanical regulation of tissue morphogenesis (79.1)
نویسندگان
چکیده
منابع مشابه
Mechanical control of tissue morphogenesis.
Mechanical forces participate in morphogenesis from the level of individual cells to whole organism patterning. This article reviews recent research that has identified specific roles for mechanical forces in important developmental events. One well defined example is that dynein-driven cilia create fluid flow that determines left-right patterning in the early mammalian embryo. Fluid flow is al...
متن کاملMechanical control of tissue morphogenesis during embryological development.
Twenty years ago, we proposed a model of developmental control based on tensegrity architecture, in which tissue pattern formation in the embryo is controlled through mechanical interactions between cells and extracellular matrix (ECM) which place the tissue in a state of isometric tension (prestress). The model proposed that local changes in the mechanical compliance of the ECM, for example, d...
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The ramified architectures of organs such as the mammary gland and lung are generated via branching morphogenesis, a developmental process through which individual cells bud and pinch off of pre-existing epithelial sheets. Although specified by signaling programs, organ development requires integration of all aspects of the microenvironment. We describe the essential role of endogenous cellular...
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Establishing and maintaining epithelial polarity is crucial during development and for adult tissue homeostasis. A complex network of evolutionarily conserved proteins regulates this compartmentalization. One such protein is Crumbs, a type I transmembrane protein initially shown to be an important apical determinant in Drosophila. We discuss recent studies that have advanced our understanding o...
متن کاملMechanical aspects of mesenchymal morphogenesis.
Many embryonic cells generate substantial contractile forces as they spread and crawl. These forces mechanically deform each cell's local environment, and the resulting distortions can alter subsequent cell movements by convection and the mechanisms of contact guidance and haptotaxis. Here we develop a model for the cumulative effects of these cell-generated forces and show how they can lead to...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2014
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.28.1_supplement.79.1