MCM7 as a marker of postsurgical progression in non-functioning pituitary adenomas
نویسندگان
چکیده
منابع مشابه
Gender-related differences in non-functioning pituitary adenomas.
OBJECTIVES Clinically non-functioning pituitary adenomas are common tumors of the pituitary gland. No studies have yet documented gender-related differences in the growth and presentation of these tumors and nothing is known about their effects on their subsequent surgical outcome and prognosis. SETTING AND DESIGN Twenty-eight patients with non-functioning pituitary adenoma, that met strict i...
متن کاملMedical therapy for clinically non-functioning pituitary adenomas.
Surgery is the first-line treatment of patients with clinically non-functioning pituitary adenomas (NFAs). Because of lack of clinical syndrome these tumours are diagnosed with a variable delay, when patients suffer from compression symptoms (hypopituitarism, headache and visual field defects) due to the extension of the tumour outside the pituitary fossa. Surgery is followed by residual tumour...
متن کاملExpression of genes FOLR1, BAG1 and LAPTM4B in functioning and non-functioning pituitary adenomas.
INTRODUCTION The mechanism of pathogenesis of adenomas pituitary is still unknown; differences between pituitary cells of different origin are observed. Identification of genes specific to pituitary adenomas should give better understanding of differences in their response to therapy, especially to radiotherapy. The aim of our study was to independently validate differences in the expression of...
متن کاملIs Positive Staining of Non-Functioning Pituitary Adenomas for Luteinizing Hormone Associated with a Poor Prognosis?
AIM The aim of this study was to assess the relationships among immunohistochemical staining patterns and prognostic factors in patients with non-functioning pituitary adenoma (NFPA). MATERIAL AND METHODS The study included 103 patients who had undergone pituitary surgery for NFPAs. The prognostic factors evaluated were initial tumor size, cavernous sinus invasion, compression of the optic ch...
متن کاملFSH secretion predominates in vivo and in vitro in patients with non-functioning pituitary adenomas.
OBJECTIVE Non-functioning pituitary adenomas (NFPAs) are characterised by the lack of symptoms of hormone hypersecretory syndromes but in vitro studies have demonstrated that tumour cells may stain for gonadotrophins and/or their alpha- or beta-subunits. In this study, we aimed to examine the pattern of secretion of LH and FSH from a series of pituitary adenomas cultured in vitro and where data...
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 2021
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje-20-1086