Molecular profiling for acromegaly treatment: a validation study
نویسندگان
چکیده
منابع مشابه
construction and validation of a computerized adaptive translation test (a receptive based study)
آزمون انطباقی رایانه ای (cat) روشی نوین برای سنجش سطح علمی دانش آموزان می باشد. در حقیقت آزمون های رایانه ای با سرعت بالایی به سمت و سوی جایگزین عملی برای آزمون های کاغذی می روند (کینگزبری، هاوسر، 1993). مقاله حاضر به دنبال آزمون انطباقی رایانه ای برای ترجمه می باشد. بدین منظور دو پرسشنامه مشتمل بر 55 تست ترجمه میان 102 آزمودنی و 10 مدرس زبان انگلیسی پخش گردید. پرسشنامه اول میان 102 دانشجوی س...
Current treatment guidelines for acromegaly.
Acromegaly, an indolent disorder of growth hormone (GH) hypersecretion is most typically caused by a somatotroph cell adenoma and may be treated by several modalities. Transsphenoidal surgical resection of micro-adenomas by experienced neurosurgeons results in biochemical normalization (postglucose GH <2 ng/mL, assay-dependent, age- and sex-matched IGF-I levels) in 70% of patients. However, ove...
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This multicenter cohort study assessed the impact of molecular profiling (MP) on advanced pancreaticobiliary cancer (PBC). The study included 30 patients treated with MP-guided therapy after failing ≥ 1 therapy for advanced PBC. Treatment was considered as having benefit for the patient if the ratio between the longest progression-free survival (PFS) on MP-guided therapy and the PFS on the last...
متن کاملAcromegaly pathogenesis and treatment.
Dysregulated growth hormone (GH) hypersecretion is usually caused by a GH-secreting pituitary adenoma and leads to acromegaly - a disorder of disproportionate skeletal, tissue, and organ growth. High GH and IGF1 levels lead to comorbidities including arthritis, facial changes, prognathism, and glucose intolerance. If the condition is untreated, enhanced mortality due to cardiovascular, cerebrov...
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“Aging is not a beautiful thing.“ This sentence is heard by many patients of acromegaly at their visit to the doctor. The changes in the body are often not recognized or misclassified by medical professionals for a very long time. Often, a diagnosis is only reached after 9 or even 10 years. A visit to the endocrinologist can shed light on the condition, however. There is an excess production of...
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ژورنال
عنوان ژورنال: Endocrine-Related Cancer
سال: 2020
ISSN: 1351-0088,1479-6821
DOI: 10.1530/erc-18-0565