Neighborhood Psychosocial Environment, Apolipoprotein E Genotype, and Cognitive Function in Older Adults
نویسندگان
چکیده
منابع مشابه
Neighborhood psychosocial environment, apolipoprotein E genotype, and cognitive function in older adults.
CONTEXT The social environment may influence cognitive function in aging. However, to our knowledge, no studies have investigated whether specific genes modify this association. OBJECTIVE To examine whether the apolipoprotein E (APOE) ε4 allele modifies the association of neighborhood psychosocial hazards and cognitive function. DESIGN A cross-sectional analysis. SETTING The Baltimore Mem...
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Recognition of dated and contemporary famous faces, short-term memory, and visuospatial abilities were investigated in adults aged 75 years and older as a function of apolipoprotein E (APOE) genotype, epsilon4 or not epsilon4, and whether participants recorded normal or low levels of B vitamins. No associations between B vitamins and APOE were identified in respect to short-term memory or visuo...
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BACKGROUND Previous studies suggest that the ε4 and ε2 alleles of apolipoprotein E (APOE) may be associated with decreased and increased risks of CKD, respectively, but there are limited data in older adults. We evaluated the associations of apolipoprotein E alleles with kidney function among older adults in the cardiovascular health study (CHS). METHODS Caucasian participants had APOE alleli...
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BACKGROUND/AIMS Because poor lung function may be a risk factor for cognitive decline, we aimed to test the association of respiratory function with cognitive function and dementia later in life, as well as potential effect modification by APOE epsilon4 carrier status. METHODS In a prospective population-based cohort study, forced vital capacity and forced expiratory flow were measured around...
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BACKGROUND Glucose intolerance and apolipoprotein ε4 allele (E4+) are risk factors for Alzheimer's disease (AD). Insulin sensitizers show promise for treating AD, but are less effective in E4+ individuals. Little is known about how the APOE genotype influences glucose metabolism. METHODS Cross-sectional analysis of 319 older adults who underwent oral glucose tolerance tests; a subset had insu...
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ژورنال
عنوان ژورنال: Archives of General Psychiatry
سال: 2011
ISSN: 0003-990X
DOI: 10.1001/archgenpsychiatry.2011.6