None of the above: thrombotic microangiopathy beyond TTP and HUS

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An update on the thrombotic microangiopathies hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP).

Welcome to this special issue of Seminars in Thrombosis & Hemostasis, which summarizes up-to-date knowledge on pathogenesis, diagnosis, and treatment of thrombotic microangiopathies (TMAs) such as (enterohemorrhagic) E. coli (EHEC)–associated hemolytic uremic syndrome (HUS) (eHUS), atypical HUS (aHUS), (aHUS) and thrombotic thrombocytopenic purpura (TTP). This issue also reviews C3 glomerulopat...

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TTP-HUS associated with sunitinib.

Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS) is a rare condition that is severe and may be fatal. Adverse reactions to drugs increasingly are reported as probable causes of TTP-HUS. Many chemotherapeutic agents have also been implicated in causing TTP-HUS. We reported a woman with metastatic renal cell carcinoma who presented with TTP-HUS associated with sunitinib. Sh...

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A support group for patients who have recovered from thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS): The six-year experience of the Oklahoma TTP-HUS Study Group.

A support group for patients who have recovered from thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS), named The Oklahoma TTP-HUS Study Group, has been a successful program for 6 years. This group has met 3 times each year with an average attendance of 16 former patients; in addition, an average of 14 family members and friends have attended each meeting. Eighty-four perc...

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[IV. Others: 1. Hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP)].

A. Agent Hemolytic uremic syndrome (HUS) is a syndrome of anemia, renal failure and low platelet count, for which there are several causes. Among children, the most common cause of HUS is infection with a Shiga toxin-producing organism, most commonly Escherichia coli O157:H7 or some other strain of enterohemorrhagic E. coli (EHEC). Shigella dysenteriae also produces Shiga toxin and HUS can also...

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Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS): a 24-year clinical experience with 178 patients

BACKGROUND Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome (TTP-HUS) are related and uncommon disorders with a high fatality and complication rate if untreated. Plasma exchange therapy has been shown to produce high response rates and improve survival in patients with many forms of TTP-HUS. We performed a retrospective cohort study of 178 consecutively treated patients wit...

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ژورنال

عنوان ژورنال: Blood

سال: 2017

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood-2016-11-743104