Novel Mechanism for Endothelial Dysfunction
نویسندگان
چکیده
منابع مشابه
Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase.
BACKGROUND Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS). Plasma levels of ADMA are elevated in individuals with hypercholesterolemia or atherosclerosis. We postulated that reduced degradation of ADMA may play a role in the accumulation of ADMA in these individuals. Accordingly, we studied the effects of oxidized LDL (oxLDL) or tumor necrosis facto...
متن کاملNeurogenic retrograde arterial flow during obstructive sleep apnea: a novel mechanism for endothelial dysfunction?
Neurogenic Retrograde Arterial Flow During Obstructive Sleep Apnea: A Novel Mechanism for Endothelial Dysfunction? To the Editor: Patients with obstructive sleep apnea (OSA) exhibit impaired brachial artery flow-mediated dilation during wakefulness, a phenomenon that has been attributed to a carryover into the awake state of the consequences of recurrent cycles of hypoxia and reperfusion during...
متن کاملEndothelial dysfunction as a cellular mechanism for vascular failure.
The regulation of vascular tone, vascular permeability, and thromboresistance is essential to maintain blood circulation and therefore tissue environments under physiological conditions. Atherogenic stimuli, including diabetes, dyslipidemia, and oxidative stress, induce vascular dysfunction, leading to atherosclerosis, which is a key pathological basis for cardiovascular diseases such as ischem...
متن کاملNovel mechanisms of endothelial dysfunction in diabetes
Diabetes mellitus is a major risk factor for cardiovascular morbidity and mortality. This condition increases the risk of developing coronary, cerebrovascular, and peripheral arterial disease fourfold. Endothelial dysfunction is a major contributor to the pathogenesis of vascular disease in diabetes mellitus patients and has recently received increased attention. In this review article, some re...
متن کاملDevelopment of Novel Arginase Inhibitors for Therapy of Endothelial Dysfunction
Endothelial dysfunction and resulting vascular pathology have been identified as an early hallmark of multiple diseases, including diabetes mellitus. One of the major contributors to endothelial dysfunction is a decrease in nitric oxide (NO) bioavailability, impaired NO signaling, and an increase in the amount of reactive oxygen species (ROS). In the endothelium NO is produced by endothelial ni...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 1999
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.99.24.3092