منابع مشابه
Connexin43 Modulation of Osteoblast/Osteocyte Apoptosis: A Potential Therapeutic Target?
GAP JUNCTIONS ARE arrays of transcellular channels that allow aqueous continuity between the cytoplasms of two adjacent cells. A gap junction channel is established by docking of two “hemichannels” or connexons present on juxtaposed cells, thus forming a transcellular conduit through which ions and small molecules can diffuse from cell to cell. Each connexon is composed of a hexameric array of ...
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PURPOSE The purpose of this study was to determine whether bisphosphonate treatment can prevent or delay osteocyte apoptosis in a cyclic fatigue animal model and if there are differences between two different bisphosphonates in their effects on osteocyte apoptosis. INTRODUCTION Fatigue loading induces microdamage in long bones in rats and causes osteocyte apoptosis. In vitro data suggest that...
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Thiazolidinediones (TZDs) increase peripheral tissue insulin sensitivity in patients with type 2 diabetes mellitus by activating the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma). In bone marrow stromal cell cultures and in vivo, activation of PPARgamma by high doses (20 mg/kg/day) of TZDs has been reported to alter stem cell differentiation by promoting commitme...
متن کاملiNOS expression and osteocyte apoptosis in idiopathic, non-traumatic osteonecrosis
BACKGROUND AND PURPOSE Non-traumatic osteonecrosis is a progressive disease with multiple etiologies. It affects younger individuals more and more, often leading to total hip arthroplasty. We investigated whether there is a correlation between inducible nitric oxide synthase (iNOS) expression and osteocyte apoptosis in non-traumatic osteonecrosis. PATIENTS AND METHODS We collected and studied...
متن کاملPrevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin.
Glucocorticoid-induced osteoporosis may be due, in part, to increased apoptosis of osteocytes and osteoblasts, and bisphosphonates (BPs) are effective in the management of this condition. We have tested the hypothesis that BPs suppress apoptosis in these cell types. Etidronate, alendronate, pamidronate, olpadronate, or amino-olpadronate (IG9402, a bisphosphonate that lacks antiresorptive activi...
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ژورنال
عنوان ژورنال: Bone
سال: 2013
ISSN: 8756-3282
DOI: 10.1016/j.bone.2012.11.038