منابع مشابه
p-glycoprotein quantitation in acute leukemia
multi drug resistance(mdr) is a major problem in the treatment of cancer and hemalological malignancies. this resistance is multi factorial and is the result of decreased intra cellular drug accumulation. this is partly due to the presence of a 170kd intra membranous protein termed p-glycoprotein(p-gp) that is an energy-dependent efflux pump which has increased expression on drug-resistance cel...
متن کاملP-glycoprotein and tumor progression.
Development of resistance to chemotherapy is a hallmark of many advanced human cancers. The molecular basis of clinical resistance is not well understood. Over the past 15 years, a number of different molecular mechanisms of resistance to anticancer drugs have been identified in many cell lines. One mechanism involves the increased expression of the plasma membrane P-glycoprotein (Pgp), which i...
متن کاملThe P-glycoprotein multidrug transporter.
Pgp (P-glycoprotein) (ABCB1) is an ATP-powered efflux pump which can transport hundreds of structurally unrelated hydrophobic amphipathic compounds, including therapeutic drugs, peptides and lipid-like compounds. This 170 kDa polypeptide plays a crucial physiological role in protecting tissues from toxic xenobiotics and endogenous metabolites, and also affects the uptake and distribution of man...
متن کاملP-Glycoprotein in clinical cardiology.
Ever since Juliano and Ling first described P-glycoprotein (P-gp) in 1975, it has become an important focus of research. P-gp is a member of the ATP-binding cassette (ABC) superfamily of proteins that is highly conserved in distantly related species (from simple eukaryotes to vertebrates). These similarities across species suggest that P-gp plays an important role in physiological processes in ...
متن کاملPharmacokinetics and pharmacodynamics of alfentanil in P-glycoprotein-competent and P-glycoprotein-deficient mice: P-glycoprotein efflux alters alfentanil brain disposition and antinociception.
Previous studies have indicated that P-glycoprotein (P-gp) attenuates the central nervous system penetration and central activity of some opioids. The impact of P-gp-mediated efflux on the disposition and efficacy of the synthetic opioid alfentanil currently is unknown. In this study, P-gp-competent [mdr1a(+/+)] and P-gp-deficient [mdr1a(-/-)] mice were used to investigate the impact of P-gp-me...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.37.21839