منابع مشابه
Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle.
Muscle inactivity due to injury or disease results in muscle atrophy. The molecular mechanisms contributing to muscle atrophy are poorly understood. However, it is clear that expression of atrophy-related genes, like Atrogin-1 and MuRF-1, are intimately tied to loss of muscle mass. When these atrophy-related genes are knocked out, inactive muscles retain mass. Muscle denervation stimulates musc...
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Lack of physical activity can cause a muscle to atrophy. Muscle deconditioning may become apparent within days to weeks of decreased physical activity. For example, we have all known individuals who were physically fit during their high school days and then became less active over time. The cessation of regular activity causes the muscles to decrease in size, but contrary to what some people sa...
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Skeletal muscle atrophy has extreme adverse consequences. Molecular mechanisms that mediate the process of atrophy are not well defined. Recent studies have focused on diverse molecular cascades that control the activation of ubiquitin ligases, indicating that the involvement of the ubiquitin proteasome may be common to a range of atrophic stimuli.
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ژورنال
عنوان ژورنال: Journal of Experimental Biology
سال: 2012
ISSN: 1477-9145,0022-0949
DOI: 10.1242/jeb.070078