Rules for drug trials should be tightened, say experts

Methotrexate Should be First in Rheumatoid Arthritis, EULAR Guidelines Say

In rheumatoid arthritis, there are two targets for treatment — sustained remission or low disease activity. Anything other than those two responses should prompt a change in treatment. The best results for patients with rheumatoid arthritis typically comes through combinations of therapeutic agents and when one treatment fails there are options for rescue therapy which are spelled out in the re...

Benchmarks for "scheduled" cases unwise, experts say.

How should zoster trials be conducted?

In 1994, an international group of interested clinicians and biostatisticians met to discuss the design of clinical trials in herpes zoster. They agreed that trials in herpes zoster should have prospectively agreed definitions of all outcome measures and plans for data analysis. In immunocompetent individuals, in whom pain is the major outcome measure, trials should only include patients over t...

I-14: Assisted Reproduction and Religion What Consideration Should Be and Should Not Be Relevant,

Several important issues are pertinent to an ethical discussion of the new technology today grouped under the name Assisted Reproduction Technology (ART). This is a moral imperative because each of us must decide what is to be considered ethically acceptable in assisted reproduction. Reflecting on the ethical dimension of ‘creating’ a new human life can play a major role in ensuring that in eac...

External validity of trials should be taken into account before asthma drug candidates reach market authorisation.