Staphylococcus aureus Endocarditis

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Staphylococcus Aureus Bacteraemia and Endocarditis

Staphylococcus aureus is a major cause of bloodstream infections and endocarditis. S. aureus bacteraemia (SAB) is associated with substantial morbidity and mortality, and endocarditis is a severe complication. Population-based studies on S. aureus bacteraemia have been sparse, and few large studies exist on S. aureus endocarditis (SAE). The objective of this thesis was to study the epidemiology...

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Clindamycin therapy of experimental Staphylococcus aureus endocarditis.

The efficacy of clindamycin in the treatment of experimental endocarditis in rabbits was compared with that of nafcillin. Both drugs were administered intramuscularly three times daily for 5 days, clindamycin at doses of 6.25, 12.5, 25, or 50 mg/kg and nafcillin at a dose of 200 mg/kg. The minimum inhibitory and bactericidal concentrations (0.125 microgram/ml) of clindamycin for the test strain...

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Staphylococcus aureus endocarditis complicated by bilateral pneumothorax.

Staphylococcus aureus is the most common cause of endocarditis in intravenous drug users. The organism gains access by intravenous injection or from the direct invasion of skin at injection sites. Known for its aggressiveness, the right sided endocarditis that ensues can lead to complications such as pulmonary abscesses and even death. We report the unusual case of an intravenous drug abuser, w...

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Methicillin-resistant Staphylococcus aureus infective endocarditis

Methicillin was introduced in 1959 to treat penicillin-resistant S. aureus infection, however Methicillin-resistant S. aureus (MRSA) was reported 2 years later (1). The most common organism identified in acute infective endocarditis (AIE) is still S. aureus associated with increased hospital mortality, morbidity and hospitalization. In Germany the proportion of MRSA among S. aureus microbiologi...

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Nafcillin therapy for Staphylococcus aureus endocarditis.

Semisynthetic penicillinase-resistant penicillins are recommended for therapy of Staphylococcus aureus endocarditis, but evaluation of the efficacy and safety of individual agents has received little attention. At The New York Hospital, 11 heroin addicts and 5 nonaddicts were treated with nafcillin. The 11 addicts did well clinically, but four of the five nonaddicts had severe complications, an...

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ژورنال

عنوان ژورنال: JAMA

سال: 2005

ISSN: 0098-7484

DOI: 10.1001/jama.293.24.3012