Susceptibility of Cholangiocarcinoma Cells to Parthenolide-Induced Apoptosis
نویسندگان
چکیده
منابع مشابه
Susceptibility of cholangiocarcinoma cells to parthenolide-induced apoptosis.
Cholangiocarcinomas are intrahepatic bile duct carcinomas that are known to have a poor prognosis. Sesquiterpene lactone parthenolide, which is the principal active component in medicinal plants, has been used to treat tumors. Parthenolide effectively induced apoptosis in all four cholangiocarcinoma cell lines in a dose-dependent manner. However, the sarcomatous SCK cells were more sensitive to...
متن کاملIdentification of the genes involved in enhanced fenretinide-induced apoptosis by parthenolide in human hepatoma cells.
Fenretinide (N-4-hydroxyphenyl retinamide, 4HPR) is a synthetic anticancer retinoid that is a well-known apoptosis-inducing agent. Recently, we observed that the apoptosis induced by fenretinide could be effectively enhanced in hepatoma cells by a concomitant treatment with parthenolide, which is a known inhibitor of nuclear factor-kappaB (NF-kappaB). Furthermore, treatment with fenretinide tri...
متن کاملHydrogen peroxide-induced apoptosis of human lens epithelial cells is inhibited by parthenolide.
AIM To explore the effect of parthenolide on hydrogen peroxide (H2O2)-induced apoptosis in human lens epithelial (HLE) cells. METHODS The morphology and number of apoptotic HLE cells were assessed using light microscopy and flow cytometry. Cell viability was tested by MTS assay. In addition, the expression of related proteins was measured by Western blot assay. RESULTS Apoptosis of HLE cell...
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Human cholangiocarcinomas evade apoptosis by overexpression of Mcl-1. The drug obatoclax (GX15-070) inhibits antiapoptotic members of the Bcl-2 family including Mcl-1. The purpose of this study is to determine if obatoclax sensitizes human cholangiocarcinoma cells to apoptosis. The human cholangiocarcinoma cell lines, KMCH, KMBC, and TFK, were employed for these studies. Protein expression was ...
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We and others have recently found that mature murine B cells can be induced to undergo apoptosis, in vitro, in a dose-dependent manner, by extensive crosslinking of membrane IgM with polyclonal anti-mu. During the analysis of tolerance in transgenic mice expressing rearranged IgM or IgM + IgD receptors, we observed that, Sp6 anti-TNP Ig and anti-MHC transgenic splenocytes, would undergo recepto...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2005
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-04-4193