Targeting the gut-liver axis in liver disease
نویسندگان
چکیده
منابع مشابه
Alcoholic liver disease and the gut-liver axis.
Alcoholic liver disease (ALD) is one of the leading causes of liver diseases and liver-related death worldwide. Of the many factors that contribute to the pathogenesis of ALD, gut-derived lipopolysaccharide (LPS) plays a central role in induction of steatosis, inflammation, and fibrosis in the liver. In this review, we discuss the mechanisms by which alcohol contributes to increased gut permeab...
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Non-alcoholic fatty liver disease (NAFLD) is the most frequent type of chronic liver disease in the pediatric age group, paralleling an obesity pandemic. A "multiple-hit" hypothesis has been invoked to explain its pathogenesis. The "first hit" is liver lipid accumulation in obese children with insulin resistance. In the absence of significant lifestyle modifications leading to weight loss and i...
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The pathogenesis of hepatic encephalopathy (HE) involves the interaction between two pathophysiological mechanisms: ammonia detoxification and inflammation. The neuropathology of HE is characterised by astrocyte dysfunction and swelling due to ammonia detoxification. The enzyme glutamine synthetase, which is located mainly in astrocytes, protects neurons by absorbing excess ammonia and glutamat...
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The incidence of obesity and its related conditions, including non-alcoholic fatty liver disease (NAFLD), has dramatically increased in all age groups worldwide. Given the health consequences of these conditions, and the subsequent economic burden on healthcare systems, their prevention and treatment have become major priorities. Because standard dietary and lifestyle changes and pathogenically...
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'Detoxification' of gut-derived toxins and microbial products from gut-derived microbes is a major role of the liver. While the full repertoire of gut-derived microbial products that reach the liver in health and disease is yet to be explored, the levels of bacterial lipopolysaccharide (LPS), a component of Gram-negative bacteria, is increased in the portal and/or systemic circulation in severa...
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ژورنال
عنوان ژورنال: Journal of Hepatology
سال: 2017
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2017.05.007