The problem of perfect predictors in statistical spike train models
نویسندگان
چکیده
Generalized Linear Models (GLMs) have been used extensively in statistical models of spike train data. However, the maximum likelihood estimates model parameters and their uncertainty, can be challenging to compute situations where response non-response separated by a single predictor or linear combination multiple predictors. Such are likely arise many neural systems due properties such as refractoriness incomplete sampling signals that influence spiking. In this paper, we describe classes approaches address problem: using an optimization algorithm with fixed iteration limit, computing solution Bayesian estimation, regularization, change basis, modifying search parameters. We demonstrate specific application each these methods spiking data from rat somatosensory cortex discuss advantages disadvantages each. also provide example roadmap for selecting method based on problem's particular analysis issues scientific goals.
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Acknowledgments We are grateful to S.N. Baker for organizing the EPSRCfunded Newcastle workshop on Spike Train Analysis, which inspired the writing of this review. We thank M. Diamond and E. Arabzadeh for sharing their data, and P.E. Latham, L. Paninski and J.D. Victor for useful discussions and insightful comments. Our research was supported by Pfizer Global Development (SP,RS), EPSRC EP/C0108...
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ژورنال
عنوان ژورنال: Neurons, behavior, data analysis, and theory
سال: 2021
ISSN: ['2690-2664']
DOI: https://doi.org/10.51628/001c.27667